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KMID : 0379520060220040333
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한국독성학회지
2006 Volume.22 No. 4 p.333 ~ p.338
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Anti-Oxidative Effects of Ulva lactuca Extract Fractions Against CCl_4 Toxification
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Nam Chun-Suk
Kang Kum-Suk
Ha Jong-Myung
Lee Sang-Hyeon
Lee Jae-Hwa
Lee Dong-Geun
Jang Jeong-Su
Kang Hwan-Yul
Ha Bae-Jin
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Abstract
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This study was to investigate the preventive effects in anti-oxidation of Ulva lactuca extract fractions (ULEF) against CCl_4 toxification in liver total homogenate and mitochondrial fraction of ULEF-pretreated and carbon tetrachloride (CCl_4)-posttreated rats. ULEF was intraperitoneally administered into rats at dose of 1 ml/kg for14 days. On the day 15, 3.3 ml/kg of CCl_4 dissolved in olive oil (1:1) was injected 12 hr before anesthetization. Activities of superoxide dismutase(SOD) in mitochondrial fraction were measured and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver total homogenate. SOD, CAI and GPx were higher in the ULEF-pretreated and CCl_4-posttreated group than those in the CCl_4-posttreated group, and the pretreatment of ULEF decreased MDA. These results showed that the pretreatment of ULEF had the preventive role in the activities of anti-oxidative enzymes, SOD, CAT and GPx
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KEYWORD
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Ulva iactuca extract fraction, Carbon tetrachloride, Anti-oxidative effects
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